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Principal Investigator
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Address
TUM University Hospital
Klinikum rechts der Isar
Department of Neurosurgery
Ismaninger Str. 22
81675 Munich
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Phone
+49-89-4140-7636
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Email
simon.jacob[at]tum.de
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Research topics
Cellular and circuit basis of higher cognition • Working memory, executive control, language • Prefrontal cortex • Brain-computer interfaces
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Scientific Approach
We investigate cognitive mechanisms in
animal models and in humans. To study
specific brain functions, we design and
train controlled behavioral tasks. We
then combine multiple state-of-the-art
techniques in mice, including
large-scale extracellular recordings,
optogenetic manipulation of defined cell
types and networks, fluorescent imaging
and computational analysis and
modelling. In a unique interdisciplinary
approach, we develop and use
technologies for recording from
populations of individual neurons in
human neurosurgical patients.
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Related Publications
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Bernklau TW, Righetti B, Mehrke LS,
Jacob SN (2024) Striatal dopamine
signals reflect perceived
cue-action-outcome associations in
mice. Nat Neurosci 27(4):747-757.
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Lin XX, Nieder A, Jacob SN (2023)
The neuronal implementation of
representational geometry in primate
prefrontal cortex. Sci Adv
9:eadh8685.
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Eisenkolb VM, Held LM, Utzschmid A,
Lin XX, Krieg SM, Meyer B, Gempt J,
Jacob SN (2023) Human acute
microelectrode array recordings with
broad cortical access, single-unit
resolution and parallel behavioral
monitoring. Cell Rep 42(5):112467.
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Hanganu-Opatz IL, Klausberger T,
Sigurdsson T, Nieder A, Jacob SN,
Bartos M, Sauer JF, Durstewitz D,
Leibold C, Diester I (2023)
Resolving the prefrontal mechanisms
of adaptive cognitive behaviors: A
cross-species perspective. Neuron.
111(7):1020-1036.
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Ploner M, Buyx A, Gempt J,
Gjorgjieva J, Müller R, Priller J,
Rückert D, Wolfrum B, Jacob SN
(2023) Reengineering
neurotechnology: placing patients
first. Nat Mental Health. 1(1)5:7.
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