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Principal Investigator
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Address
Ludwig-Maximilians-Universität
München
Department Biology
II
Grosshadernerstr. 2
82152
Planegg-Martinsried
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Email
busse[at]bio.lmu.de
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Research topics
Context has powerful influences on
perception and on the neural
activity in sensory areas.
Information processing occurs
through the concerted action of
specific cell types in neuronal
assemblies to guide sensation and
behavior. We investigate the
influence of context on sensory
representations in the visual
system at the level of the neuronal
circuit. How do specific cells and
circuits relate to visual
processing, and how they drive
behaviour?
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Scientific approach
To monitor activity in local
populations of the neuronal circuit
we use multi-channel extracellular
recordings in awake behaving mice.
In several projects, we train mice
to perform highly controlled visual
tasks. We combine these neural
recordings with causal manipulations
of circuit elements using genetic
tools, such as optogenetics.
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Related Publications
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Khastkhodaei, Z., Jurjut, O.,
Katzner, S., and Busse, L.
(2016). Mice can use
second-order, contrast-modulated
stimuli to guide visual
perception. J Neurosci,
36(16):4457–69.
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Erisken, S., Vaiceliunaite, A.,
Jurjut, O., Fiorini, M.,
Katzner, S., and Busse, L.
(2014). Effects of locomotion
extend throughout the mouse
early visual system. Current
Biology, 24(24):2899– 2907.
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Vaiceliunaite, A., Erisken, S.,
Franzen, F., Katzner, S., and
Busse, L. (2013). Spatial
integration in mouse primary
visual cortex. Journal of
Neurophysiology, 110(4):964–972.
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Busse, L., Ayaz, A., Dhruv, N.
T., Katzner, S., Saleem, A. B.,
Schölvinck, M. L., Zaharia, A.
D., and Carandini, M. (2011).
The detection of visual contrast
in the behaving mouse. The
Journal of Neuroscience,
31(31):11351–11361.
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Busse, L., Wade, A. R., and
Carandini, M. (2009).
Representation of concurrent
stimuli by population activity
in visual cortex. Neuron,
64(6):931–942.
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