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Research topics
Humans and other animals need to
perceive and react to sensory signals to
survive and flourish in their
environment. The perception of sensory
signals, in turn, is highly dynamic and
strongly shaped by physiological and
bodily states including the level of
arousal, motor movements and attention.
The overarching goal of our research
group is to decipher the precise
mechanisms in the brain by which
physiological and bodily states shape
our perception and how disruptions in
these mechanisms contribute to the
etiology of psychiatric disorders.
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Scientific Approach
For our research, we make use of in vivo
intracellular and extracellular
high-density neural recordings, mouse
behavior, and optogenetics.
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Related Publications
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Nestvogel D.B., McCormick DA.,
Visual Thalamocortical Mechanisms of
Waking State-Dependent Activity and
Alpha Oscillations (2022). Neuron
110, 120-138.e4
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McCormick, D. A., Nestvogel, D. B.,
& He, B. J. (2020). Neuromodulation
of Brain State and Behavior. Annual
Review of Neuroscience.
https://doi.org/10.1146/annurev-neuro-100219-105424
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Nestvogel, D.B., Merino, R.M.,
Leon-Pinzon, C., Schottdorf, M.,
Lee, C., Imig, C., Brose, N., and
Rhee, J.-S. (2020). The Synaptic
Vesicle Priming Protein CAPS-1
Shapes the Adaptation of Sensory
Evoked Responses in Mouse Visual
Cortex. Cell Reports 30,
3261–3269.e4.
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Neske, G.T., Nestvogel, D., Steffan,
P.J., and McCormick, D.A. (2019).
Distinct Waking States for Strong
Evoked Responses in Primary Visual
Cortex and Optimal Visual Detection
Performance. Journal of Neuroscience
39, 10044–10059.
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