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Principal Investigator
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Address
Ludwig-Maximilians-Universität
München
Faculty of Biology
Grosshadernerstr. 2
82152
Planegg-Martinsried
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Email
sirota[at]biologie.uni-muenchen.de
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Research Topics
Our research is focused on the
mechanisms of information
representation and propagation
within and across different cortical
networks. Specifically, we are
exploring the neurophysiological
mechanisms of information transfer
within and between the neocortex and
hippocampus during learning
(acquisition) and sleep
(consolidation), as one of the key
topics in learning and memory
research.
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Scientific Approach
We employ state-of-the-art
multichannel extracellular
recordings in different cortical
areas in behaving rats. Recordings
with multichannel silicon probes
allow us to sample the activity of
multiple single neurons and local
field potentials across multiple
layers of one or several cortical
areas. We employ various
perturbation techniques, such as
electrical stimulation and
optogenetic modulation of
neuronal activity. We pioneered
high-resolution tracking of animal
motion that allow for quantitative
and precise analysis of natural
behavior of the animal. Our research
involves advanced signal processing
and data mining, as well as
computational modeling.
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Recent Publications
OPEN ACCESS LMU
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Anatomically resolved
oscillatory bursts reveal
dynamic motifs of
thalamocortical activity
during naturalistic stimulus
viewing
Lukas S Meyerolbersleben,
A Sirota, L Busse
Neuron (2025)
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Multi‐Shank 1024 Channels
Active SiNAPS Probe for
Large Multi‐Regional
Topographical
Electrophysiological Mapping
of Neural Dynamics
Gian Nicola Angotzi et
al.
Advanced Science (2025)
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Over and above frequency:
Gamma oscillations as units
of neural circuit
operations
Fernandez-Ruiz, Antonio;
Sirota, Anton; Lopes-dos-Santos,
Vitor; Dupret, David
Neuron, Vol. 111, Issue 7
(2023)
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Multishank Thin-Film Neural
Probes and Implantation
System for High-Resolution
Neural Recording
Applications
Middya, Sagnik;
Carnicer-Lombarte, Alejandro;
Curto, Vincenzo F.; Hilton, Sam;
Genewsky, Andreas J.; Rutz,
Alexandra L.; Barone, Damiano G;
Kaminski Schierle, Gabriele S.;
Sirota, Anton; Malliaras, George
G.
Advanced Electronic
Material (2022)
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Breathing modulates
cortico-hippocampal dynamics
in mice during offline
states.
Karalis, N; Sirota,
Anton
Nature Communications, Vol.
13, No. 467 (2022)
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