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Principal
Investigator
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Address
Ludwig-Maximilians-Universität
München
Faculty of Biology
Grosshadernerstr.
2
82152
Planegg-Martinsried
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Email
sirota[at]biologie.uni-muenchen.de
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Research topics
Our research is focused on the
mechanisms of information
representation and propagation
within and across different
cortical networks. Specifically,
we are exploring the
neurophysiological mechanisms
of information transfer within
and between the neocortex and
hippocampus during learning
(acquisition) and sleep
(consolidation), as one of
the key topics in learning and
memory research.
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Scientific Approach
We employ state-of-the-art
multichannel extracellular
recordings in different cortical
areas in behaving rats.
Recordings with
multichannel silicon probes
allow us to sample the activity
of multiple single neurons and
local field potentials across
multiple layers of one
or several cortical areas. We
employ various perturbation
techniques, such as electrical
stimulation and optogenetic
modulation of neuronal activity.
We pioneered high-resolution
tracking of animal motion
that allow for quantitative and
precise analysis of natural
behavior of the animal. Our
research involves advanced
signal processing and
data mining, as well as
computational modeling.
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Over and above
frequency: Gamma
oscillations as units of
neural circuit
operations
Fernandez-Ruiz,
Antonio; Sirota, Anton;
Lopes-dos-Santos, Vitor;
Dupret, David
Neuron, Vol. 111, Issue
7 (2023)
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Multishank Thin-Film
Neural Probes and
Implantation System for
High-Resolution Neural
Recording
Applications
Middya, Sagnik;
Carnicer-Lombarte,
Alejandro; Curto, Vincenzo
F.; Hilton, Sam; Genewsky,
Andreas J.; Rutz, Alexandra
L.; Barone, Damiano G;
Kaminski Schierle, Gabriele
S.; Sirota, Anton;
Malliaras, George G.
Advanced Electronic
Material (2022)
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Breathing modulates
cortico-hippocampal
dynamics in mice during
offline states.
Karalis, N; Sirota,
Anton
Nature Communications,
Vol. 13, No. 467
(2022)
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